Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly

The Ski2-Ski3-Ski8 (Ski238) helicase complex directs cytoplasmic mRNAs toward the nucleolytic exosome complex for degradation. In yeast, the interaction between Ski238 and exosome requires the adaptor protein Ski7. We determined different cryo-EM structures of the Ski238 complex depicting the transi...

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Detalles Bibliográficos
Autores principales: Keidel, Achim, Kögel, Alexander, Reichelt, Peter, Kowalinski, Eva, Schäfer, Ingmar B., Conti, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659929/
https://www.ncbi.nlm.nih.gov/pubmed/37879335
http://dx.doi.org/10.1016/j.molcel.2023.09.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659929/
https://www.ncbi.nlm.nih.gov/pubmed/37879335
http://dx.doi.org/10.1016/j.molcel.2023.09.037

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