Genome homeostasis defects drive enlarged cells into senescence

Cellular senescence refers to an irreversible state of cell-cycle arrest and plays important roles in aging and cancer biology. Because senescence is associated with increased cell size, we used reversible cell-cycle arrests combined with growth rate modulation to study how excessive growth affects...

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Detalles Bibliográficos
Autores principales: Manohar, Sandhya, Estrada, Marianna E., Uliana, Federico, Vuina, Karla, Alvarez, Patricia Moyano, de Bruin, Robertus A.M., Neurohr, Gabriel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659931/
https://www.ncbi.nlm.nih.gov/pubmed/37977116
http://dx.doi.org/10.1016/j.molcel.2023.10.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659931/
https://www.ncbi.nlm.nih.gov/pubmed/37977116
http://dx.doi.org/10.1016/j.molcel.2023.10.018

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