Geranylgeranylacetone reduces cardiomyocyte stiffness and attenuates diastolic dysfunction in a rat model of cardiometabolic syndrome

Titin‐dependent stiffening of cardiomyocytes is a significant contributor to left ventricular (LV) diastolic dysfunction in heart failure with preserved LV ejection fraction (HFpEF). Small heat shock proteins (HSPs), such as HSPB5 and HSPB1, protect titin and administration of HSPB5 in vitro lowers...

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Detalles Bibliográficos
Autores principales: Waddingham, Mark T., Sequeira, Vasco, Kuster, Diederik W. D., Dal Canto, Elisa, Handoko, M. Louis, de Man, Frances S., da Silva Gonçalves Bós, Denielli, Ottenheijm, Coen A., Shen, Shengyi, van der Pijl, Robbert J., van der Velden, Jolanda, Paulus, Walter J., Eringa, Etto C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659935/
https://www.ncbi.nlm.nih.gov/pubmed/37985159
http://dx.doi.org/10.14814/phy2.15788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659935/
https://www.ncbi.nlm.nih.gov/pubmed/37985159
http://dx.doi.org/10.14814/phy2.15788

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