Synthetic Dual Cysteine-ADP Ribosylated Peptides from the Androgen Receptor are Recognized by the DTX3L/PARP9 Complex

[Image: see text] Androgen signaling in prostate cancer cells involves multisite cysteine ADP-ribosylation of the androgen receptor (AR) by PARP7. The AR modification is read by ADP-ribosyl binding macrodomains in PARP9, but the reason that multiple cysteines are modified is unknown. Here, we use sy...

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Detalles Bibliográficos
Autores principales: Wijngaarden, Sven, Yang, Chunsong, Vela-Rodríguez, Carlos, Lehtiö, Lari, Overkleeft, Herman S., Paschal, Bryce M., Filippov, Dmitri V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660311/
https://www.ncbi.nlm.nih.gov/pubmed/37939374
http://dx.doi.org/10.1021/acschembio.3c00305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660311/
https://www.ncbi.nlm.nih.gov/pubmed/37939374
http://dx.doi.org/10.1021/acschembio.3c00305

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