Cargando…

BRCA-mutated gastric adenocarcinomas are associated with chromosomal instability and responsiveness to platinum-based chemotherapy

BACKGROUND: Homologous recombination defect is an important biomarker of chemotherapy in certain tumor types, and the presence of pathogenic or likely pathogenic mutations involving BRCA1 or BRCA2 (p-BRCA) mutations is the most well-established marker for the homologous recombination defect. Gastric...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oh, Ji Hyun, Sung, Chang Ohk, Kim, Hyung-Don, Chun, Sung-Min, Kim, Jihun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Pathologists and the Korean Society for Cytopathology 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660362/ https://www.ncbi.nlm.nih.gov/pubmed/37981726 http://dx.doi.org/10.4132/jptm.2023.10.22

Ejemplares similares

The effects of BRCA1 expression on the chemosensitivity of gastric cancer cells to platinum agents
por: Kim, Geon, et al.
Publicado: (2019)

Clinical Utility of a Fully Automated Microsatellite Instability Test with Minimal Hands-on Time
por: Lee, Miseon, et al.
Publicado: (2019)

Platinum response characteristics of patients with pancreatic ductal adenocarcinoma and a germline BRCA1, BRCA2 or PALB2 mutation
por: Wattenberg, Max M., et al.
Publicado: (2019)

Adjuvant Chemotherapy in Microsatellite Instability–High Gastric Cancer
por: Kim, Jin Won, et al.
Publicado: (2020)

Spontaneous mutations in the single TTN gene represent high tumor mutation burden
por: Oh, Ji-Hye, et al.
Publicado: (2020)

Platinum-Based Neoadjuvant Chemotherapy for Breast Cancer With BRCA Mutations: A Meta-Analysis
por: Wang, Chang-Jun, et al.
Publicado: (2020)

A Genomic Instability Score in Discriminating Nonequivalent Outcomes of BRCA1/2 Mutations and in Predicting Outcomes of Ovarian Cancer Treated with Platinum-Based Chemotherapy
por: Zhang, Shaojun, et al.
Publicado: (2014)

Microsatellite Instability in Korean Patients with Gastric Adenocarcinoma
por: Jee, Mi Seon, et al.
Publicado: (1997)

Role of BRCA Mutations in the Modulation of Response to Platinum Therapy
por: Mylavarapu, Sanghamitra, et al.
Publicado: (2018)

Histopathologic and Molecular Biomarkers of PD-1/PD-L1 Inhibitor Treatment Response among Patients with Microsatellite Instability–High Colon Cancer
por: Hyung, Jaewon, et al.
Publicado: (2022)

Effect of platinum-based chemotherapy on EGFR gene mutation status in lung adenocarcinoma
por: Wang, Yuli, et al.
Publicado: (2018)

Adenocarcinoma derived from gastric hamartomatous polyps
por: Oh, Seung Jong, et al.
Publicado: (2011)

Morphological characteristics of vasculogenic mimicry and its correlation with EphA2 expression in gastric adenocarcinoma
por: Kim, Hee Sung, et al.
Publicado: (2019)

The effect of neoadjuvant platinum-based chemotherapy in BRCA mutated triple negative breast cancers -systematic review and meta-analysis
por: Caramelo, Olga, et al.
Publicado: (2019)

Platinum-Based Versus Non-Platinum-Based Chemotherapy as First Line Treatment of Inoperable, Advanced Gastric Adenocarcinoma: A Meta-Analysis
por: Chen, Wei-Wei, et al.
Publicado: (2013)

Chromosomal Instability in Gastric Cancer Biology
por: Maleki, Saffiyeh Saboor, et al.
Publicado: (2017)

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells
por: Petrov, Nikolai, et al.
Publicado: (2021)

The Efficacy of Platinum Chemotherapy in a Japanese Malignant Melanoma Patient With a BRCA2 Mutation Identified by Gene Panel Testing
por: Takayanagi-Hara, Reiko, et al.
Publicado: (2023)

Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer
por: Bae, Yoon Sung, et al.
Publicado: (2015)

Third-line docetaxel chemotherapy for recurrent and metastatic gastric cancer
por: Lee, Ji Hyun, et al.
Publicado: (2013)

Exome sequencing in a breast cancer family without BRCA mutation
por: Noh, Jae Myoung, et al.
Publicado: (2015)

Platinum chemotherapy for BRCA1-related breast cancer: do we need more evidence?
por: Turner, Nicholas C, et al.
Publicado: (2012)

BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer
por: Stefansson, Olafur A., et al.
Publicado: (2012)

The expression of ERCC1 and BRCA1 predicts prognosis of platinum-based chemotherapy in urothelial cancer
por: Song, Wenhui, et al.
Publicado: (2016)

A novel germline BRCA2 mutation in a Chinese patient with prostate cancer sensitive to platinum chemotherapy: a case report
por: Jiang, Lijuan, et al.
Publicado: (2021)

A narrative review of Safety management of 1 L platinum-based chemotherapy and maintenance olaparib in BRCA mutated advanced pancreatic cancer
por: Yao, Jiayu, et al.
Publicado: (2021)

High chromosomal instability in adenocarcinoma of the ileum arising from multifocal gastric heterotopia with gastritis cystica profunda
por: Schaefer, Inga-Marie, et al.
Publicado: (2010)

Four distinct immune microenvironment subtypes in gastric adenocarcinoma with special reference to microsatellite instability
por: Cho, Junhun, et al.
Publicado: (2018)

BRCA1-associated protein 1 expression and prognostic role in prostate adenocarcinoma
por: Oh, Harim, et al.
Publicado: (2020)

Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms
por: Kim, Young Beak, et al.
Publicado: (2016)

Clinical significance of BRCA1 and BRCA2 mRNA and protein expression in patients with sporadic gastric cancer
por: Kim, Hee Sung, et al.
Publicado: (2019)

Prevalence of BRCA1 and BRCA2 Mutations in Korean Breast Cancer Patients
por: Ahn, Sei Hyun, et al.
Publicado: (2004)

Mutation at Intronic Repeats of the Ataxia-Telangiectasia Mutated (ATM) Gene and ATM Protein Loss in Primary Gastric Cancer with Microsatellite Instability
por: Kim, Hee Sung, et al.
Publicado: (2013)

Radiofrequency Ablation for Hepatic Metastasis from Gastric Adenocarcinoma
por: An, Ji Yeong, et al.
Publicado: (2008)

Biallelic variants in BRCA1 gene cause a recognisable phenotype within chromosomal instability syndromes reframed as BRCA1 deficiency
por: Chirita-Emandi, Adela, et al.
Publicado: (2021)

A systematic review and meta-analysis of BRCA1/2 mutation for predicting the effect of platinum-based chemotherapy in triple-negative breast cancer
por: Jia, Xiaomeng, et al.
Publicado: (2022)

Prognostic Factors of Second and Third Line Chemotherapy Using 5-FU with Platinum, Irinotecan, and Taxane for Advanced Gastric Cancer
por: Park, Ji Soo, et al.
Publicado: (2011)

First successful case of platinum‐based chemotherapy for neuroendocrine prostate cancer with BRCA2 and PTEN alterations
por: Omura, Minami, et al.
Publicado: (2021)

Combining PARP inhibitors and platinum-based chemotherapy in metastatic triple negative and/or BRCA-associated breast cancer
por: Molto Valiente, Consolacion, et al.
Publicado: (2023)

Differential Pathogenesis of Lung Adenocarcinoma Subtypes Involving Sequence Mutations, Copy Number, Chromosomal Instability, and Methylation
por: Wilkerson, Matthew D., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_eg0r1og1mqt7m5dpamr4lq8a4m