Atypical Asparagine Deamidation of NW Motif Significantly Attenuates the Biological Activities of an Antibody Drug Conjugate

Asparagine deamidation is a post-translational modification (PTM) that converts asparagine residues into iso-aspartate and/or aspartate. Non-enzymatic asparagine deamidation is observed frequently during the manufacturing, processing, and/or storage of biotherapeutic proteins. Depending on the site...

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Detalles Bibliográficos
Autores principales: Cao, Mingyan, Hussmann, G. Patrick, Tao, Yeqing, O’Connor, Ellen, Parthemore, Conner, Zhang-Hulsey, Diana, Liu, Dengfeng, Jiao, Yang, de Mel, Niluka, Prophet, Meagan, Korman, Samuel, Sonawane, Jaytee, Grigoriadou, Christina, Huang, Yue, Umlauf, Scott, Chen, Xiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660493/
https://www.ncbi.nlm.nih.gov/pubmed/37987246
http://dx.doi.org/10.3390/antib12040068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660493/
https://www.ncbi.nlm.nih.gov/pubmed/37987246
http://dx.doi.org/10.3390/antib12040068

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