CD8(+) chimeric antigen receptor T cells manufactured in absence of CD4(+) cells exhibit hypofunctional phenotype

BACKGROUND: Cell culture conditions during manufacturing can impact the clinical efficacy of chimeric antigen receptor (CAR) T cell products. Production methods have not been standardized because the optimal approach remains unknown. Separate CD4(+) and CD8(+) cultures offer a potential advantage bu...

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Detalles Bibliográficos
Autores principales: Lee, Sang Yun, Lee, Dong Hoon, Sun, Wei, Cervantes-Contreras, Francisco, Basom, Ryan S, Wu, Feinan, Liu, Si, Rai, Richa, Mirzaei, Hamid R, O’Steen, Shyril, Green, Damian J, Shadman, Mazyar, Till, Brian G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660840/
http://dx.doi.org/10.1136/jitc-2023-007803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660840/
http://dx.doi.org/10.1136/jitc-2023-007803

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