Use of Farnesyl Transferase Inhibitors in an Ageing Model in Drosophila

The presence of farnesylated proteins at the inner nuclear membrane (INM), such as the Lamins or Kugelkern in Drosophila, leads to specific changes in the nuclear morphology and accelerated ageing on the organismal level reminiscent of the Hutchinson–Gilford progeria syndrome (HGPS). Farnesyl transf...

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Detalles Bibliográficos
Autores principales: Brandt, Annely, Petrovsky, Roman, Kriebel, Maria, Großhans, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660854/
https://www.ncbi.nlm.nih.gov/pubmed/37987370
http://dx.doi.org/10.3390/jdb11040040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660854/
https://www.ncbi.nlm.nih.gov/pubmed/37987370
http://dx.doi.org/10.3390/jdb11040040

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