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Conformational features and interaction mechanisms of V(H)H antibodies with β‐hairpin CDR3: A case of Nb8‐HigB2 interaction

The β‐hairpin conformation is regarded as an important basic motif to form and regulate protein–protein interactions. Single‐domain V(H)H antibodies are potential therapeutic and diagnostic tools, and the third complementarity‐determining regions of the heavy chains (CDR3s) of these antibodies are c...

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Detalles Bibliográficos
Autores principales: Yamamoto, Koichi, Nagatoishi, Satoru, Matsunaga, Ryo, Nakakido, Makoto, Kuroda, Daisuke, Tsumoto, Kouhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661080/
https://www.ncbi.nlm.nih.gov/pubmed/37916305
http://dx.doi.org/10.1002/pro.4827