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JUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia
Dexamethasone (Dex) plays a critical role in T-ALL treatment, but the mechanisms of Dex resistance are poorly understood. Here, we demonstrated that the expression of JUN was regulated in Dex-resistant T-ALL cell lines and patient samples. JUN knockdown increased the sensitivity to Dex. Moreover, th...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661119/ https://www.ncbi.nlm.nih.gov/pubmed/38026210 http://dx.doi.org/10.1016/j.isci.2023.108242 |