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JUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia

Dexamethasone (Dex) plays a critical role in T-ALL treatment, but the mechanisms of Dex resistance are poorly understood. Here, we demonstrated that the expression of JUN was regulated in Dex-resistant T-ALL cell lines and patient samples. JUN knockdown increased the sensitivity to Dex. Moreover, th...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhijie, Shi, Jiangzhou, Wu, Qifang, Zhang, Zijian, Liu, Xiaoyan, Ren, Anqi, Zhao, Guanlin, Dong, Ge, Wu, Han, Zhao, Jiaxuan, Zhao, Yuan, Hu, Jia, Li, Hui, Zhang, Tongcun, Zhou, Fuling, Zhu, Haichuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661119/ https://www.ncbi.nlm.nih.gov/pubmed/38026210 http://dx.doi.org/10.1016/j.isci.2023.108242

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