Impact of mutations defining SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 on Spike function and neutralization

Additional mutations in the viral Spike protein helped the BA.2.12.1 and BA.4/5 SARS-CoV-2 Omicron subvariants to outcompete the parental BA.2 subvariant. Here, we determined the functional impact of mutations that newly emerged in the BA.2.12.1 (L452Q, S704L) and BA.4/5 (Δ69-70, L452R, F486V, R493Q...

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Detalles Bibliográficos
Autores principales: Pastorio, Chiara, Noettger, Sabrina, Nchioua, Rayhane, Zech, Fabian, Sparrer, Konstantin M.J., Kirchhoff, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661123/
https://www.ncbi.nlm.nih.gov/pubmed/38026181
http://dx.doi.org/10.1016/j.isci.2023.108299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661123/
https://www.ncbi.nlm.nih.gov/pubmed/38026181
http://dx.doi.org/10.1016/j.isci.2023.108299

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