Astrocyte-targeted siRNA delivery by adenosine-functionalized LNP in mouse TBI model

Traumatic brain injury (TBI) induces pro-inflammatory polarization of astrocytes and causes secondary disruption of the blood-brain barrier (BBB) and brain damage. Herein, we report a successful astrocyte-targeted delivery of small interfering RNA (siRNA) by ligand functionalized lipid nanoparticles...

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Detalles Bibliográficos
Autores principales: Xiao, Hai, Amarsaikhan, Odmaa, Zhao, Yunwang, Yu, Xiang, Hu, Xin, Han, Shuqin, Chaolumen, Baigude, Huricha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661454/
https://www.ncbi.nlm.nih.gov/pubmed/38028196
http://dx.doi.org/10.1016/j.omtn.2023.102065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661454/
https://www.ncbi.nlm.nih.gov/pubmed/38028196
http://dx.doi.org/10.1016/j.omtn.2023.102065

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