Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly

Glial-cell line derived neurotrophic factor (GDNF) bound to its co-receptor GFRα1 stimulates the RET receptor tyrosine kinase, promoting neuronal survival and neuroprotection. The GDNF-GFRα1 complex also supports synaptic cell adhesion independently of RET. Here, we describe the structure of a decam...

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Detalles Bibliográficos
Autores principales: Houghton, F. M., Adams, S. E., Ríos, A. S., Masino, L., Purkiss, A. G., Briggs, D. C., Ledda, F., McDonald, N. Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661694/
https://www.ncbi.nlm.nih.gov/pubmed/37985758
http://dx.doi.org/10.1038/s41467-023-43148-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661694/
https://www.ncbi.nlm.nih.gov/pubmed/37985758
http://dx.doi.org/10.1038/s41467-023-43148-8

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