Application of NMR and Chemometric Analyses to Better Understand the Quality Attributes in pH and Thermally Degraded Monoclonal Antibodies

PURPOSE: Nuclear magnetic resonance (NMR) spectroscopy provides the sensitivity and specificity to probe the higher order structure (HOS) of monoclonal antibodies (mAbs) for potential changes. This study demonstrates an application of chemometric tools to measure differences in the NMR spectra of mA...

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Detalles Bibliográficos
Autores principales: Beaumont, Victor A., Liu, Lucy, Shi, Heliang, Rouse, Jason C., Kim, Hai-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661726/
https://www.ncbi.nlm.nih.gov/pubmed/37798537
http://dx.doi.org/10.1007/s11095-023-03600-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661726/
https://www.ncbi.nlm.nih.gov/pubmed/37798537
http://dx.doi.org/10.1007/s11095-023-03600-2

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