A Perfused In Vitro Human iPSC-Derived Blood–Brain Barrier Faithfully Mimics Transferrin Receptor-Mediated Transcytosis of Therapeutic Antibodies

Delivering biologics to elicit a therapeutic response in the central nervous system (CNS) remains challenging due to the presence of the blood–brain barrier (BBB). Receptor-mediated transcytosis is a strategy to improve brain exposure after systemic drug administration. The availability of a clinica...

Descripción completa

Detalles Bibliográficos
Autores principales: Burgio, Floriana, Gaiser, Carine, Brady, Kevin, Gatta, Viviana, Class, Reiner, Schrage, Ramona, Suter-Dick, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661771/
https://www.ncbi.nlm.nih.gov/pubmed/37698826
http://dx.doi.org/10.1007/s10571-023-01404-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661771/
https://www.ncbi.nlm.nih.gov/pubmed/37698826
http://dx.doi.org/10.1007/s10571-023-01404-x

Ejemplares similares