Mechanism of Insoluble Aggregate Formation in a Reconstituted Solution of Spray-Dried Protein Powder

BACKGROUND: Spray-drying is considered a promising alternative drying method to lyophilization (freeze-drying) for therapeutic proteins. Particle counts in reconstituted solutions of dried solid dosage forms of biologic drug products are closely monitored to ensure product quality. We found that hig...

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Detalles Bibliográficos
Autores principales: Tao, Yeqing, Chen, Yuan, Howard, Wesley, Ibrahim, Mariam, Patel, Sajal M., McMahon, William P., Kim, Yoen Joo, Delmar, Jared A., Davis, Darryl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661820/
https://www.ncbi.nlm.nih.gov/pubmed/37131104
http://dx.doi.org/10.1007/s11095-023-03524-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661820/
https://www.ncbi.nlm.nih.gov/pubmed/37131104
http://dx.doi.org/10.1007/s11095-023-03524-x

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