Leucine‐rich repeat kinase 2 (LRRK2) inhibition upregulates microtubule‐associated protein 1B to ameliorate lysosomal dysfunction and parkinsonism

Mutations in LRRK2 (encoding leucine‐rich repeat kinase 2 protein, LRRK2) are the most common genetic risk factors for Parkinson's disease (PD), and increased LRRK2 kinase activity was observed in sporadic PD. Therefore, inhibition of LRRK2 has been tested as a disease‐modifying therapeutic str...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Kang, Tang, Fei, Du, Bin, Yue, Zhe‐Zhou, Jiao, Ling‐Ling, Ding, Xu‐Long, Tuo, Qing‐Zhang, Meng, Jie, He, Si‐Yu, Dai, Lunzhi, Lei, Peng, Wei, Xia‐Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661827/
https://www.ncbi.nlm.nih.gov/pubmed/38020716
http://dx.doi.org/10.1002/mco2.429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661827/
https://www.ncbi.nlm.nih.gov/pubmed/38020716
http://dx.doi.org/10.1002/mco2.429

Ejemplares similares