Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening

Enhancing the properties of advanced drug candidates is aided by the direct incorporation of specific chemical groups, avoiding the need to construct the entire compound from the ground up. Nevertheless, their chemical intricacy often poses challenges in predicting reactivity for C-H activation reac...

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Detalles Bibliográficos
Autores principales: Nippa, David F., Atz, Kenneth, Müller, Alex T., Wolfard, Jens, Isert, Clemens, Binder, Martin, Scheidegger, Oliver, Konrad, David B., Grether, Uwe, Martin, Rainer E., Schneider, Gisbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661846/
https://www.ncbi.nlm.nih.gov/pubmed/37985850
http://dx.doi.org/10.1038/s42004-023-01047-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661846/
https://www.ncbi.nlm.nih.gov/pubmed/37985850
http://dx.doi.org/10.1038/s42004-023-01047-5

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