Cargando…
Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening
Enhancing the properties of advanced drug candidates is aided by the direct incorporation of specific chemical groups, avoiding the need to construct the entire compound from the ground up. Nevertheless, their chemical intricacy often poses challenges in predicting reactivity for C-H activation reac...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661846/ https://www.ncbi.nlm.nih.gov/pubmed/37985850 http://dx.doi.org/10.1038/s42004-023-01047-5 |