Multiparametric domain insertional profiling of adeno-associated virus VP1

Several evolved properties of adeno-associated virus (AAV), such as broad tropism and immunogenicity in humans, are barriers to AAV-based gene therapy. Most efforts to re-engineer these properties have focused on variable regions near AAV’s 3-fold protrusions and capsid protein termini. To comprehen...

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Detalles Bibliográficos
Autores principales: Hoffmann, Mareike D., Zdechlik, Alina C., He, Yungui, Nedrud, David, Aslanidi, George, Gordon, Wendy, Schmidt, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661864/
https://www.ncbi.nlm.nih.gov/pubmed/38027057
http://dx.doi.org/10.1016/j.omtm.2023.101143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661864/
https://www.ncbi.nlm.nih.gov/pubmed/38027057
http://dx.doi.org/10.1016/j.omtm.2023.101143

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