In vivo Metabolism of Nifurtimox and the Drug-Drug Interaction Potential Including its Major Metabolites

BACKGROUND: Nifurtimox is an effective treatment for patients with Chagas disease, but knowledge of its biotransformation and excretion is limited. OBJECTIVE: This study aimed to better understand the fate of oral nifurtimox in vivo. METHODS: We investigated the exposure and excretion pathways of [(...

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Detalles Bibliográficos
Autores principales: Schulz, Simone I., Lang, Dieter, Schmuck, Gabriele, Gerisch, Michael, Bairlein, Michaela, Fricke, Robert, Stass, Heino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2023
Materias:
Drug Design, Discovery and Therapy, Drug Delivery, Pharmacology, Drug Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661964/
https://www.ncbi.nlm.nih.gov/pubmed/37592798
http://dx.doi.org/10.2174/1389200224666230817114758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10661964/
https://www.ncbi.nlm.nih.gov/pubmed/37592798
http://dx.doi.org/10.2174/1389200224666230817114758

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