Genome mining for macrolactam-encoding gene clusters allowed for the network-guided isolation of β-amino acid-containing cyclic derivatives and heterologous production of ciromicin A

β-Amino acid-containing macrolactams represent a structurally diverse group of bioactive natural products derived from polyketides; however we are currently lacking a comprehensive overview about their abundance across bacterial families and the underlying biosynthetic diversity. In this study, we e...

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Detalles Bibliográficos
Autores principales: Seibel, Elena, Um, Soohyun, Dayras, Marie, Bodawatta, Kasun H., de Kruijff, Martinus, Jønsson, Knud A., Poulsen, Michael, Kim, Ki Hyun, Beemelmanns, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662134/
https://www.ncbi.nlm.nih.gov/pubmed/37985888
http://dx.doi.org/10.1038/s42004-023-01034-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662134/
https://www.ncbi.nlm.nih.gov/pubmed/37985888
http://dx.doi.org/10.1038/s42004-023-01034-w

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