Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9–mediated genome engineering in HAP1 cells mimicking cancer profiles

The CRISPR-Cas9 system is a powerful tool for studying gene functions and holds potential for disease treatment. However, precise genome editing requires thorough assessments to minimize unintended on- and off-target effects. Here, we report an unexpected 283-kb deletion on Chromosome 10 (10q23.31)...

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Detalles Bibliográficos
Autores principales: Geng, Keyi, Merino, Lara G, Veiga, Raül G, Sommerauer, Christian, Epperlein, Janine, Brinkman, Eva K, Kutter, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662290/
https://www.ncbi.nlm.nih.gov/pubmed/37984988
http://dx.doi.org/10.26508/lsa.202302128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662290/
https://www.ncbi.nlm.nih.gov/pubmed/37984988
http://dx.doi.org/10.26508/lsa.202302128

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