Mutant p53 murine oviductal epithelial cells induce progression of high-grade serous carcinoma and are most sensitive to simvastatin therapy in vitro and in vivo

High-grade serous carcinoma (HGSC) is the most common and aggressive subtype of epithelial ovarian cancer, characterized by gain-of-function TP53 mutations originating in the fallopian tube epithelium. Therapeutic intervention occurs at advanced metastatic disease, due to challenges in early-stage d...

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Detalles Bibliográficos
Autores principales: Pereira, Madison, Glogova, Alice, Haagsma, Jacob, Stewart, Julia, Shepherd, Trevor G., Petrik, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662458/
https://www.ncbi.nlm.nih.gov/pubmed/37986175
http://dx.doi.org/10.1186/s13048-023-01307-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662458/
https://www.ncbi.nlm.nih.gov/pubmed/37986175
http://dx.doi.org/10.1186/s13048-023-01307-x

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