Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impairment in mice

BACKGROUND: Previously we reported that inhibition of GPR17 prevents amyloid β 1–42 (Aβ(1-42))-induced cognitive impairment in mice. However, the role of GPR17 on cognition is still largely unknown. METHODS: Herein, we used a mouse model of cognitive impairment induced by lipopolysaccharide (LPS) to...

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Detalles Bibliográficos
Autores principales: Liang, Yusheng, kang, Xu, Zhang, Haiwang, Xu, Heng, Wu, Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662506/
https://www.ncbi.nlm.nih.gov/pubmed/37990234
http://dx.doi.org/10.1186/s12974-023-02958-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662506/
https://www.ncbi.nlm.nih.gov/pubmed/37990234
http://dx.doi.org/10.1186/s12974-023-02958-9

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