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Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impairment in mice
BACKGROUND: Previously we reported that inhibition of GPR17 prevents amyloid β 1–42 (Aβ(1-42))-induced cognitive impairment in mice. However, the role of GPR17 on cognition is still largely unknown. METHODS: Herein, we used a mouse model of cognitive impairment induced by lipopolysaccharide (LPS) to...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662506/ https://www.ncbi.nlm.nih.gov/pubmed/37990234 http://dx.doi.org/10.1186/s12974-023-02958-9 |