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The promotion of sestrin2/AMPK signaling by HIF-1α overexpression enhances the damage caused by acute myocardial infarction

OBJECTIVE: Acute myocardial infarction (AMI), is a serious form of coronary heart disease. The present study sought to investigate the impact of HIF-1α on AMI, along with its fundamental mechanism. METHODS: Sprague-Dawley (SD) rats were used to conduct an AMI model. 2,3,5-triphenyl-2H-tetrazolium ch...

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Detalles Bibliográficos
Autores principales: Wang, Jie, Du, Honglei, Sun, Qing, Wan, Weiping, Zhang, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662688/
https://www.ncbi.nlm.nih.gov/pubmed/37986153
http://dx.doi.org/10.1186/s12872-023-03604-1