Effects of N-glycan modifications on spike expression, virus infectivity, and neutralization sensitivity in ancestral compared to Omicron SARS-CoV-2 variants

The SARS-CoV-2 spike glycoprotein has 22 potential N-linked glycosylation sites per monomer that are highly conserved among diverse variants, but how individual glycans affect virus entry and neutralization of Omicron variants has not been extensively characterized. Here we compared the effects of s...

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Detalles Bibliográficos
Autores principales: Lusvarghi, Sabrina, Stauft, Charles B., Vassell, Russell, Williams, Brittany, Baha, Haseebullah, Wang, Wei, Neerukonda, Sabari Nath, Wang, Tony, Weiss, Carol D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662749/
https://www.ncbi.nlm.nih.gov/pubmed/37943965
http://dx.doi.org/10.1371/journal.ppat.1011788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662749/
https://www.ncbi.nlm.nih.gov/pubmed/37943965
http://dx.doi.org/10.1371/journal.ppat.1011788

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