Origins of Enhanced Enantioselectivity in the Pd-Catalyzed Decarboxylative Allylic Alkylation of N-Benzoyl Lactams ()

We explore the origins of the marked improvement in enantioselectivity in the inner-sphere (PHOX)Pd-catalyzed allylic alkylation of N-benzoyl lactam nucleophiles over their carbocyclic counterparts. We employ density functional theory calculations to aid in the interpretation of experimental results...

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Detalles Bibliográficos
Autores principales: Cusumano, Alexander Q., Zhang, Tianyi, Goddard, William A., Stoltz, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662798/
https://www.ncbi.nlm.nih.gov/pubmed/37990660
http://dx.doi.org/10.3390/catal13091258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662798/
https://www.ncbi.nlm.nih.gov/pubmed/37990660
http://dx.doi.org/10.3390/catal13091258

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