Vitamin B(12) is a limiting factor for induced cellular plasticity and tissue repair

Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its metabolic requirements. Here we show that OSKM reprogramming in mice causes a global depletion of vitamin B(12) and molecular...

Descripción completa

Detalles Bibliográficos
Autores principales: Kovatcheva, Marta, Melendez, Elena, Chondronasiou, Dafni, Pietrocola, Federico, Bernad, Raquel, Caballe, Adrià, Junza, Alexandra, Capellades, Jordi, Holguín-Horcajo, Adrián, Prats, Neus, Durand, Sylvere, Rovira, Meritxell, Yanes, Oscar, Stephan-Otto Attolini, Camille, Kroemer, Guido, Serrano, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663163/
https://www.ncbi.nlm.nih.gov/pubmed/37973897
http://dx.doi.org/10.1038/s42255-023-00916-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663163/
https://www.ncbi.nlm.nih.gov/pubmed/37973897
http://dx.doi.org/10.1038/s42255-023-00916-6

Ejemplares similares