PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy

Senescent cells remain metabolically active, but their metabolic landscape and resulting implications remain underexplored. Here, we report upregulation of pyruvate dehydrogenase kinase 4 (PDK4) upon senescence, particularly in some stromal cell lines. Senescent cells display a PDK4-dependent increa...

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Detalles Bibliográficos
Autores principales: Dou, Xuefeng, Fu, Qiang, Long, Qilai, Liu, Shuning, Zou, Yejun, Fu, Da, Xu, Qixia, Jiang, Zhirui, Ren, Xiaohui, Zhang, Guilong, Wei, Xiaoling, Li, Qingfeng, Campisi, Judith, Zhao, Yuzheng, Sun, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663165/
https://www.ncbi.nlm.nih.gov/pubmed/37903887
http://dx.doi.org/10.1038/s42255-023-00912-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663165/
https://www.ncbi.nlm.nih.gov/pubmed/37903887
http://dx.doi.org/10.1038/s42255-023-00912-w

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