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Binding of small molecule inhibitors to RNA polymerase-Spt5 complex impacts RNA and DNA stability
Spt5 is an elongation factor that associates with RNA polymerase II (Pol II) during transcription and has important functions in promoter-proximal pausing and elongation processivity. Spt5 was also recognized for its roles in the transcription of expanded-repeat genes that are related to neurodegene...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer International Publishing
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663202/ https://www.ncbi.nlm.nih.gov/pubmed/37987925 http://dx.doi.org/10.1007/s10822-023-00543-z |