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Binding of small molecule inhibitors to RNA polymerase-Spt5 complex impacts RNA and DNA stability

Spt5 is an elongation factor that associates with RNA polymerase II (Pol II) during transcription and has important functions in promoter-proximal pausing and elongation processivity. Spt5 was also recognized for its roles in the transcription of expanded-repeat genes that are related to neurodegene...

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Detalles Bibliográficos
Autores principales:	Gallardo, Adan, Dutagaci, Bercem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663202/ https://www.ncbi.nlm.nih.gov/pubmed/37987925 http://dx.doi.org/10.1007/s10822-023-00543-z

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