The ATR inhibitor berzosertib acts as a radio- and chemosensitizer in head and neck squamous cell carcinoma cell lines

Alterations in the DNA damage response play a crucial role in radio- and chemoresistance of neoplastic cells. Activation of the Ataxia telangiectasia and Rad3-related (ATR) pathway is an important DNA damage response mechanism in head and neck squamous cell carcinoma (HNSCC). Berzosertib, a selectiv...

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Detalles Bibliográficos
Autores principales: Schnoell, Julia, Sparr, Carmen, Al-Gboore, Sega, Haas, Markus, Brkic, Faris F., Kadletz-Wanke, Lorenz, Heiduschka, Gregor, Jank, Bernhard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663216/
https://www.ncbi.nlm.nih.gov/pubmed/37934325
http://dx.doi.org/10.1007/s10637-023-01408-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663216/
https://www.ncbi.nlm.nih.gov/pubmed/37934325
http://dx.doi.org/10.1007/s10637-023-01408-w

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