Cargando…

Upregulation of LRRK2 following traumatic brain injury does not directly phosphorylate Thr(175) tau

Phosphorylated microtubule-associated protein tau (tau) aggregates are a pathological hallmark of various neurodegenerative diseases, including chronic traumatic encephalopathy and amyotrophic lateral sclerosis with cognitive impairment. While there are many residues phosphorylated on tau, phosphory...

Descripción completa

Detalles Bibliográficos
Autores principales:	Donison, Neil, Hintermayer, Matthew, Subramaniam, Maegha, Santandrea, Erin, Volkening, Kathryn, Strong, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663351/ https://www.ncbi.nlm.nih.gov/pubmed/38026695 http://dx.doi.org/10.3389/fncel.2023.1272899

Ejemplares similares

Pathologic Thr(175) tau phosphorylation in CTE and CTE with ALS
por: Moszczynski, Alexander J., et al.
Publicado: (2018)

Alterations in Tau Metabolism in ALS and ALS-FTSD
por: Strong, Michael J., et al.
Publicado: (2020)

Phosphorylation of Threonine 175 Tau in the Induction of Tau Pathology in Amyotrophic Lateral Sclerosis—Frontotemporal Spectrum Disorder (ALS-FTSD). A Review
por: Moszczynski, Alexander J., et al.
Publicado: (2018)

Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43(M337V) and tau(T175D) protein
por: Moszczynski, Alexander J., et al.
Publicado: (2019)

Threonine(175), a novel pathological phosphorylation site on tau protein linked to multiple tauopathies
por: Moszczynski, Alexander J., et al.
Publicado: (2017)

The Role of α-Synuclein and LRRK2 in Tau Phosphorylation
por: Kawakami, Fumitaka, et al.
Publicado: (2015)

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy
por: Bailey, Rachel M., et al.
Publicado: (2013)

LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth
por: Kawakami, Fumitaka, et al.
Publicado: (2012)

Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles
por: Muraoka, Satoshi, et al.
Publicado: (2021)

Increases of Phosphorylated Tau (Ser202/Thr205) in the Olfactory Regions Are Associated with Impaired EEG and Olfactory Behavior in Traumatic Brain Injury Mice
por: Yoon, Younghyun, et al.
Publicado: (2022)

Protein kinase C‐mediated phosphorylation of transient receptor potential melastatin type 2 Thr738 counteracts the effect of cytosolic Ca(2+) and elevates the temperature threshold
por: Kashio, Makiko, et al.
Publicado: (2022)

Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism
por: Taymans, Jean-Marc, et al.
Publicado: (2014)

Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity
por: Shu, Yang, et al.
Publicado: (2016)

CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease
por: Strain, Jeremy F., et al.
Publicado: (2022)

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
por: Malik, Asad U., et al.
Publicado: (2021)

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR(B) GTPase domain
por: Malik, Asad U., et al.
Publicado: (2022)

LRRK2 Phosphorylation, More Than an Epiphenomenon
por: Marchand, Antoine, et al.
Publicado: (2020)

From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson’s Disease: Lessons From LRRK2
por: Mancini, Andrea, et al.
Publicado: (2020)

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr(348) phosphorylation
por: Sartori, Maxime, et al.
Publicado: (2019)

‘Up with the LRRK’: a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement
por: Eyers, Patrick A.
Publicado: (2016)

Designing antibodies against LRRK2-targeted tau epitopes
por: Hamm, Matthew, et al.
Publicado: (2018)

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration
por: Jeong, Ga Ram, et al.
Publicado: (2018)

Dual arginine recognition of LRRK2 phosphorylated Rab GTPases
por: Waschbüsch, Dieter, et al.
Publicado: (2021)

Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics
por: Bardai, Farah H., et al.
Publicado: (2018)

Thr(435) phosphorylation regulates RelA (p65) NF-κB subunit transactivation
por: O'Shea, John M., et al.
Publicado: (2010)

Cdk1-Mediated Phosphorylation of Human ATF7 at Thr-51 and Thr-53 Promotes Cell-Cycle Progression into M Phase
por: Hasegawa, Hitomi, et al.
Publicado: (2014)

Increased Ratio of Global O-GlcNAcylation to Tau Phosphorylation at Thr212 Site Is Associated With Better Memory Function in Patients With Type 2 Diabetes
por: Huang, Rong, et al.
Publicado: (2019)

Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations
por: Labrador-Garrido, Adahir, et al.
Publicado: (2023)

Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice
por: Gong, Ting, et al.
Publicado: (2022)

G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses
por: Ho, Dong Hwan, et al.
Publicado: (2019)

Phosphorylation of Mycobacterium tuberculosis Ser/Thr Phosphatase by PknA and PknB
por: Sajid, Andaleeb, et al.
Publicado: (2011)

Mass Spectrometry Offers Insight into the Role of Ser/Thr/Tyr Phosphorylation in the Mycobacteria
por: Calder, Bridget, et al.
Publicado: (2016)

Phosphorylation of caspase-9 at Thr125 directs paclitaxel resistance in ovarian cancer
por: Byun, Mi Ran, et al.
Publicado: (2017)

Phosphorylation of H3-Thr3 by Haspin Is Required for Primary Cilia Regulation
por: Quadri, Roberto, et al.
Publicado: (2021)

LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25
por: Yun, Hye Jin, et al.
Publicado: (2013)

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2(+) lysosomes
por: Kluss, Jillian H., et al.
Publicado: (2022)

Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation
por: Fasiczka, Rachel, et al.
Publicado: (2023)

Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease
por: Henderson, Michael X., et al.
Publicado: (2019)

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues
por: Iannotta, Lucia, et al.
Publicado: (2020)

THR Simulator – the software for generating radiographs of THR prosthesis
por: Wu, Tai-Yin, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_ok9ursgoih26l9csb6tovqlim5