Phosphodiesterase 4 inhibition after retrieval switches the memory fate favoring extinction instead of reconsolidation

Phosphodiesterase 4 (PDE4), an enzyme expressed in the dorsal hippocampus (DH), hydrolyzes the cAMP, limiting the PKA-induced CREB phosphorylation (pCREB) and BDNF expression. Depending on the brain region, PKA and pCREB mediate reconsolidation or extinction, whereas BDNF is mainly related to extinc...

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Detalles Bibliográficos
Autores principales: Machado Batista Sohn, Jeferson, Cardoso, Nathalie Carla, Raymundi, Ana Maria, Prickaerts, Jos, Stern, Cristina Aparecida Jark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663466/
https://www.ncbi.nlm.nih.gov/pubmed/37990053
http://dx.doi.org/10.1038/s41598-023-47717-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663466/
https://www.ncbi.nlm.nih.gov/pubmed/37990053
http://dx.doi.org/10.1038/s41598-023-47717-1

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