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Phosphodiesterase 4 inhibition after retrieval switches the memory fate favoring extinction instead of reconsolidation
Phosphodiesterase 4 (PDE4), an enzyme expressed in the dorsal hippocampus (DH), hydrolyzes the cAMP, limiting the PKA-induced CREB phosphorylation (pCREB) and BDNF expression. Depending on the brain region, PKA and pCREB mediate reconsolidation or extinction, whereas BDNF is mainly related to extinc...
Autores principales: | Machado Batista Sohn, Jeferson, Cardoso, Nathalie Carla, Raymundi, Ana Maria, Prickaerts, Jos, Stern, Cristina Aparecida Jark |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663466/ https://www.ncbi.nlm.nih.gov/pubmed/37990053 http://dx.doi.org/10.1038/s41598-023-47717-1 |
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