Preclinical evidence for the effective use of TL-895, a highly selective and potent second-generation BTK inhibitor, for the treatment of B-cell malignancies

TL-895 (formerly known as M7583) is a potent, highly selective, adenosine triphosphate (ATP)-competitive, second-generation, irreversible inhibitor of Bruton’s tyrosine kinase (BTK). We characterized its biochemical and cellular effects in in vitro and in vivo models. TL-895 was evaluated preclinica...

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Detalles Bibliográficos
Autores principales: Goodstal, Samantha M., Lin, Jing, Crandall, Timothy, Crowley, Lindsey, Bender, Andrew T., Pereira, Albertina, Soloviev, Maria, Wesolowski, John S., Iadevaia, Riham, Schelhorn, Sven-Eric, Ross, Edith, Morandi, Federica, Ma, Jianguo, Clark, Anderson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663516/
https://www.ncbi.nlm.nih.gov/pubmed/37989777
http://dx.doi.org/10.1038/s41598-023-47735-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663516/
https://www.ncbi.nlm.nih.gov/pubmed/37989777
http://dx.doi.org/10.1038/s41598-023-47735-z

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