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Quantification of ligand and mutation-induced bias in EGFR phosphorylation in direct response to ligand binding
Signaling bias is the ability of a receptor to differentially activate downstream signaling pathways in response to different ligands. Bias investigations have been hindered by inconsistent results in different cellular contexts. Here we introduce a methodology to identify and quantify bias in signa...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663608/ https://www.ncbi.nlm.nih.gov/pubmed/37989743 http://dx.doi.org/10.1038/s41467-023-42926-8 |