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Mutation at the entrance of the quinone cavity severely disrupts quinone binding in respiratory complex I
In all resolved structures of complex I, there exists a tunnel-like Q-chamber for ubiquinone binding and reduction. The entrance to the Q-chamber in ND1 subunit forms a narrow bottleneck, which is rather tight and requires thermal conformational changes for ubiquinone to get in and out of the bindin...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663621/ https://www.ncbi.nlm.nih.gov/pubmed/37989876 http://dx.doi.org/10.1038/s41598-023-47314-2 |