Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity

Seleno-insulin, a class of artificial insulin analogs, in which one of the three disulfide-bonds (S-S’s) of wild-type insulin (Ins) is replaced by a diselenide-bond (Se-Se), is attracting attention for its unique chemical and physiological properties that differ from those of Ins. Previously, we pio...

Descripción completa

Detalles Bibliográficos
Autores principales: Arai, Kenta, Okumura, Masaki, Lee, Young-Ho, Katayama, Hidekazu, Mizutani, Kenji, Lin, Yuxi, Park, Sam-Yong, Sawada, Kaichiro, Toyoda, Masao, Hojo, Hironobu, Inaba, Kenji, Iwaoka, Michio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663622/
https://www.ncbi.nlm.nih.gov/pubmed/37989850
http://dx.doi.org/10.1038/s42004-023-01056-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663622/
https://www.ncbi.nlm.nih.gov/pubmed/37989850
http://dx.doi.org/10.1038/s42004-023-01056-4

Ejemplares similares