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Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity
Seleno-insulin, a class of artificial insulin analogs, in which one of the three disulfide-bonds (S-S’s) of wild-type insulin (Ins) is replaced by a diselenide-bond (Se-Se), is attracting attention for its unique chemical and physiological properties that differ from those of Ins. Previously, we pio...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663622/ https://www.ncbi.nlm.nih.gov/pubmed/37989850 http://dx.doi.org/10.1038/s42004-023-01056-4 |