Enhancement of recombinant adeno-associated virus activity by improved stoichiometry and homogeneity of capsid protein assembly

Studies of recombinant adeno-associated virus (rAAV) revealed the mixture of full particles with different densities in rAAV. There are no conclusive results because of the lack of quantitative stoichiometric viral proteins, encapsidated DNA, and particle level analyses. We report the first comprehe...

Descripción completa

Detalles Bibliográficos
Autores principales: Onishi, Takayuki, Nonaka, Michika, Maruno, Takahiro, Yamaguchi, Yuki, Fukuhara, Mitsuko, Torisu, Tetsuo, Maeda, Masaharu, Abbatiello, Susan, Haris, Anisha, Richardson, Keith, Giles, Kevin, Preece, Steve, Yamano-Adachi, Noriko, Omasa, Takeshi, Uchiyama, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663676/
https://www.ncbi.nlm.nih.gov/pubmed/38027055
http://dx.doi.org/10.1016/j.omtm.2023.101142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663676/
https://www.ncbi.nlm.nih.gov/pubmed/38027055
http://dx.doi.org/10.1016/j.omtm.2023.101142

Ejemplares similares