Transient TKI-resistant CD44+pBAD+ blasts undergo intrinsic homeostatic adaptation to promote the survival of acute myeloid leukemia in vitro

Acute myeloid leukemia (AML) patients have frequent mutations in FMS-like receptor tyrosine kinase 3 (FLT3-mut AML), who respond poorly to salvage chemotherapies and targeted therapies such as tyrosine kinase inhibitors (TKIs). Disease relapse is a common reason of treatment failures in FLT3-mut AML...

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Detalles Bibliográficos
Autores principales: Xu, Yi, Baylink, David J., Chen, Chien-Shing, Tan, Laren, Xiao, Jeffrey, Park, Brandon, Valladares, Ismael, Reeves, Mark E., Cao, Huynh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664142/
https://www.ncbi.nlm.nih.gov/pubmed/38023123
http://dx.doi.org/10.3389/fonc.2023.1286863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664142/
https://www.ncbi.nlm.nih.gov/pubmed/38023123
http://dx.doi.org/10.3389/fonc.2023.1286863

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