Lipid exchange at ER–trans-Golgi contact sites governs polarized cargo sorting

Oxysterol binding protein (OSBP) extracts cholesterol from the ER to deliver it to the TGN via counter exchange and subsequent hydrolysis of the phosphoinositide PI(4)P. Here, we show that this pathway is essential in polarized epithelial cells where it contributes not only to the proper subcellular...

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Detalles Bibliográficos
Autores principales: Kovács, Dávid, Gay, Anne-Sophie, Debayle, Delphine, Abélanet, Sophie, Patel, Amanda, Mesmin, Bruno, Luton, Frédéric, Antonny, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664280/
https://www.ncbi.nlm.nih.gov/pubmed/37991810
http://dx.doi.org/10.1083/jcb.202307051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664280/
https://www.ncbi.nlm.nih.gov/pubmed/37991810
http://dx.doi.org/10.1083/jcb.202307051

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