Cargando…

TH-302-loaded nanodrug reshapes the hypoxic tumour microenvironment and enhances PD-1 blockade efficacy in gastric cancer

BACKGROUND: Hypoxia, a common characteristic of the tumour microenvironment, is involved in tumour progression and immune evasion. Targeting the hypoxic microenvironment has been implicated as a promising antitumour therapeutic strategy. TH-302 can be selectively activated under hypoxic conditions....

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Zhixiong, Zhu, Menglin, Dong, Runyu, Cao, Danping, Li, Yanna, Chen, Zhiqiang, Cai, Juan, Zuo, Xueliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664313/ https://www.ncbi.nlm.nih.gov/pubmed/37993847 http://dx.doi.org/10.1186/s12951-023-02203-8

Ejemplares similares

Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302
por: Lohse, Ines, et al.
Publicado: (2016)

The hypoxic tumour microenvironment
por: Petrova, Varvara, et al.
Publicado: (2018)

Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment
por: Wang, Wenyu, et al.
Publicado: (2020)

m(6)A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion
por: Cao, Xiaoxue, et al.
Publicado: (2023)

Hypoxic targeting and activating TH-302 loaded transcatheter arterial embolization microsphere
por: Ma, Pengkai, et al.
Publicado: (2020)

Exosome secretion from hypoxic cancer cells reshapes the tumor microenvironment and mediates drug resistance
por: To, Kenneth K. W., et al.
Publicado: (2022)

PD-1 and TIGIT blockade differentially affect tumour cell survival under hypoxia and glucose deprived conditions in oesophageal adenocarcinoma; implications for overcoming resistance to PD-1 blockade in hypoxic tumours
por: Davern, Maria, et al.
Publicado: (2022)

Atovaquone-HSA nano-drugs enhance the efficacy of PD-1 blockade immunotherapy by alleviating hypoxic tumor microenvironment
por: Wang, Simeng, et al.
Publicado: (2021)

Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry
por: Nguyen, Teresa T, et al.
Publicado: (2022)

Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly
por: Li, Shukun, et al.
Publicado: (2020)

Immunotherapy: Reshape the Tumor Immune Microenvironment
por: LV, Bingzhe, et al.
Publicado: (2022)

Improving the synergistic combination of programmed death‐1/programmed death ligand‐1 blockade and radiotherapy by targeting the hypoxic tumour microenvironment
por: Mudassar, Faiqa, et al.
Publicado: (2022)

Reshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
por: Zhong, Fengyun, et al.
Publicado: (2023)

USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade
por: Yang, Zhaojuan, et al.
Publicado: (2021)

Tumour Regression via Integrative Regulation of Neurological, Inflammatory, and Hypoxic Tumour Microenvironment
por: Lee, Chang Hoon, et al.
Publicado: (2020)

Correction to: Reshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
por: Zhong, Fengyun, et al.
Publicado: (2023)

USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy
por: Xiong, Wenjun, et al.
Publicado: (2022)

Nanodrugs: pharmacokinetics and safety
por: Onoue, Satomi, et al.
Publicado: (2014)

The tumour microenvironment links complement system dysregulation and hypoxic signalling
por: Olcina, Monica M, et al.
Publicado: (2019)

C5aR1 blockade reshapes immunosuppressive tumor microenvironment and synergizes with immune checkpoint blockade therapy in high-grade serous ovarian cancer
por: Zhang, Chen, et al.
Publicado: (2023)

CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy
por: Chang, Yun, et al.
Publicado: (2023)

Extracellular vesicle PD-L1 in reshaping tumor immune microenvironment: biological function and potential therapy strategies
por: Liu, Jiaxing, et al.
Publicado: (2022)

Acidic and Hypoxic Microenvironment in Melanoma: Impact of Tumour Exosomes on Disease Progression
por: Boussadia, Zaira, et al.
Publicado: (2021)

Reshaping the Pancreatic Cancer Microenvironment at Different Stages with Chemotherapy
por: Peng, Maozhen, et al.
Publicado: (2023)

Nanodrugs and Natural Pharmaceutical Products
por: Abbaspour, Mohammadreza
Publicado: (2012)

Nanodrugs Detonate Lysosome Bombs
por: Xiang, Yuting, et al.
Publicado: (2022)

An intravenous anesthetic drug-propofol, influences the biological characteristics of malignant tumors and reshapes the tumor microenvironment: A narrative literature review
por: Zhou, Xueliang, et al.
Publicado: (2022)

The miR-302/367 cluster: a comprehensive update on its evolution and functions
por: Gao, Zeqian, et al.
Publicado: (2015)

Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment
por: Lv, Ji, et al.
Publicado: (2019)

Selecting suitable chemotherapies for PD-1/PD-L1 blockade to optimize the tumor immune microenvironment
por: Koyama, Shohei, et al.
Publicado: (2018)

CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target
por: Drenckhan, Astrid, et al.
Publicado: (2018)

Highlights on the Role of KRAS Mutations in Reshaping the Microenvironment of Pancreatic Adenocarcinoma
por: Hafezi, Shirin, et al.
Publicado: (2021)

Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance
por: Zhang, Aiping, et al.
Publicado: (2022)

Histone lactylation regulates cancer progression by reshaping the tumor microenvironment
por: Qu, Junxing, et al.
Publicado: (2023)

Tumor Microenvironment Cascade-Responsive Nanodrug with Self-Targeting Activation and ROS Regeneration for Synergistic Oxidation-Chemotherapy
por: Li, Yang, et al.
Publicado: (2020)

Mesoporous nanodrug delivery system: a powerful tool for a new paradigm of remodeling of the tumor microenvironment
por: Hang, Yinhui, et al.
Publicado: (2023)

Transformation of the tumour microenvironment by a CD40 agonist antibody correlates with improved responses to PD-L1 blockade in a mouse orthotopic pancreatic tumour model
por: Luheshi, Nadia M., et al.
Publicado: (2016)

Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment
por: Zheng, Jun, et al.
Publicado: (2023)

Revolutionary Impact of Nanodrug Delivery on Neuroscience
por: Khanbabaie, Reza, et al.
Publicado: (2012)

Camptothecin-based nanodrug delivery systems
por: Wen, Yan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_fehpiko0cer4ov702gptqm6ne5