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Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques

BACKGROUND: Mutagenicity, the ability of chemical agents to cause mutations and potentially lead to cancer, is a critical aspect of substance safety assessment for protecting human health and the environment. Metabolic enzymes activate multiple mutagens in living organisms, thus in vivo animal model...

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Detalles Bibliográficos
Autores principales: Izawa, Kazuki, Tsuda, Masataka, Suzuki, Takayoshi, Honma, Masamitsu, Sugiyama, Kei-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664353/
https://www.ncbi.nlm.nih.gov/pubmed/37993952
http://dx.doi.org/10.1186/s41021-023-00288-z