Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis

BACKGROUND: Irisin plays a key role in metabolic diseases, including type 2 diabetes mellitus (T2DM). However, the mechanism underlying the link between irisin and the development of T2DM, particularly in pancreatic islet β-cells, remains unknown. METHODS: In vitro, Min6 cells were treated with high...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Tianrong, Yang, Jingjing, Tan, Anjun, Chen, Hewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664367/
https://www.ncbi.nlm.nih.gov/pubmed/37993958
http://dx.doi.org/10.1186/s13098-023-01216-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664367/
https://www.ncbi.nlm.nih.gov/pubmed/37993958
http://dx.doi.org/10.1186/s13098-023-01216-5

Ejemplares similares