Captive ERVWE1 triggers impairment of 5-HT neuronal plasticity in the first-episode schizophrenia by post-transcriptional activation of HTR1B in ALKBH5-m6A dependent epigenetic mechanisms

BACKGROUND: Abnormalities in the 5-HT system and synaptic plasticity are hallmark features of schizophrenia. Previous studies suggest that the human endogenous retrovirus W family envelope (ERVWE1) is an influential risk factor for schizophrenia and inversely correlates with 5-HT4 receptor in schizo...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Xiulin, Liu, Lianzhong, Xue, Xing, Li, Xuhang, Zhao, Kexin, Zhang, Jiahang, Li, Wenshi, Yao, Wei, Ding, Shuang, Jia, Chen, Zhu, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664518/
https://www.ncbi.nlm.nih.gov/pubmed/37990254
http://dx.doi.org/10.1186/s13578-023-01167-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664518/
https://www.ncbi.nlm.nih.gov/pubmed/37990254
http://dx.doi.org/10.1186/s13578-023-01167-4

Ejemplares similares